High expression of pituitary tumor gene family is a predictor for poor prognosis of gastric cancer

Previous studies have suggested that pituitary tumor transforming gene family serves as an oncogene in human cancers. However, the underlying molecular mechanisms of (PTTG) gastric cancer are unclear. This study aimed to explore expression patterns, biological functions, and potential regulatory mechanism PTTG cells. Results showed genes were highly expressed tissues correlated with low survival outcomes. Further, it was noted regulation PTTG3P associated miR-129-5p miR-383-5p. A PTTG3P-miRNA-mRNA network established. In addition, results functional analysis revealed enriched transcription cell signaling pathways. Moreover, LinkedOmics chip technology positively PTTG2, whereas not significantly PTTG1 expression. conclusion, these show promotes occurrence development regulating has oncogenic role by parental PTTG2.